Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study.

Natàlia Vilor-TejedorGrégory OpertoTavia E EvansCarles FalconMarta Crous-BouCarolina MinguillónRaffaele CacciagliaMarta Milà-AlomàOriol Grau-RiveraMarc Suárez-CalvetDiego Garrido-MartínSebastián MoránManel EstellerHieab H AdamsJosé Luis MolinuevoRoderic GuigóJuan-Domingo Gispertnull null

Published in: Brain structure & function (2020)

To our knowledge, the present study is the first to show that carrying the BDNF Val66Met polymorphisms partially compensates the decreased on HSv associated with APOE-ε4 in middle-age cognitively unimpaired individuals.

Keyphrases

cognitive decline
healthcare
high fat diet
mild cognitive impairment
tyrosine kinase
skeletal muscle
blood brain barrier
smoking cessation
cerebral ischemia