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Endotypes of severe neutrophilic and eosinophilic asthma from multi-omics integration of U-BIOPRED sputum samples.

Nazanin Zounemat KermaniChuan-Xing LiAli VersiYusef BadiKai SunMahmoud I Abdel-AzizMartina BonattiAnke-Hilse Maitland-van der ZeeRatko DjukanovicÅsa WheelockSven-Erik DahlenPeter HowarthYike GuoKian Fan ChungIssssswan M Adcocknull null
Published in: Clinical and translational medicine (2024)
Unsupervised clustering on sputum multi-omics of asthma subjects identified 3 out of 5 clusters with predominantly severe asthma. One severe asthma cluster was linked to type 2 inflammation and sputum eosinophilia while the other 2 clusters to sputum neutrophilia. One severe neutrophilic asthma cluster was linked to Moraxella catarrhalis and to a lesser extent Haemophilus influenzae while the second cluster to activation of IL-22.
Keyphrases
  • cystic fibrosis
  • lung function
  • pulmonary tuberculosis
  • mycobacterium tuberculosis
  • chronic obstructive pulmonary disease
  • single cell
  • allergic rhinitis
  • early onset
  • oxidative stress
  • rna seq
  • african american