Mutations in the leptin-melanocortin pathway and weight loss after bariatric surgery: a systematic review and meta-analysis.

Nianrong ZhangHao WangShuman RanZhe WangBiao ZhouSiqi WangZhengqi LiBaoyin LiuYuntao NieYishan HuangHua Meng

Published in: Obesity (Silver Spring, Md.) (2024)

Mutations in leptin-melanocortin pathway genes reduce long-term weight loss after bariatric surgery, whereas this effect may not be reflected during the period of rapid weight loss within 12 months. These genetic variants increase the difficulties in maintaining patients' long-term weight loss.

Keyphrases

weight loss
bariatric surgery
roux en y gastric bypass
gastric bypass
end stage renal disease
ejection fraction
newly diagnosed
glycemic control
chronic kidney disease
obese patients
weight gain
genome wide
type diabetes
body mass index
patient reported outcomes
peritoneal dialysis