Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma.

Romain Riscal Sarah M Gardner Nathan J Coffey Madeleine Carens Clementina A Mesaros Jimmy P Xu Yizheng Xue Leah Davis Sara Demczyszyn Austin Vogt Adam S Olia Jennifer M Finan Jason Godfrey David C. Schultz Ian A Blair Brian Keith Ronen Marmorstein Nicolas Skuli M Celeste Simon

Published in: Cancer research (2024)

The bile acid biosynthetic enzyme HSD3B7 is essential for ccRCC cell survival and can be targeted to induce accumulation of cholesterol-derived oxysterols and apoptotic cell death.

Keyphrases

cell death
low density lipoprotein
cell cycle arrest
cancer therapy
drug delivery
anti inflammatory