Fabrication of An Immunostimulatory Supramolecular Nanomedicine for Potent Cancer Chemoimmunotherapy.
Xinyang YuShaolong QiFangfang CaoKai YangHongjian LiKun PengZhida LiuBing BaiMarija BuljanXiaoyuan Shawn ChenGuocan YuPublished in: JACS Au (2023)
Chemoimmunotherapy can boost strong antitumor immune responses by triggering immunogenic cell death (ICD), which highlights a promising prospect in clinical applications. However, current chemoimmunotherapy shows limited efficacy due to the low delivery efficiency and insufficient immunogenicity of available chemotherapeutic drugs. A supramolecular polymeric nanomedicine (Pt-Tu@NP) is herein reported using cucurbit[7]uril-based host-guest recognition and noncovalent self-assembly. Pt-Tu@NPs have excellent biodistribution and strongly evoke the endoplasmic reticulum stress-mediated ICD of tumor cells, triggering potent antitumor immune responses by promoting dendritic cell (DC) maturation and cytotoxic T cell infiltration. The coordinated butyrate promotes a positive feedback regulation between DCs and CD8 + T cells. Pt-Tu@NPs stimulate immune cold tumors into hot ones, working in synergy with an immune checkpoint blockade to effectively suppress tumor growth and metastasis, which suggests a promising approach for cancer chemoimmunotherapy.
Keyphrases
- dendritic cells
- immune response
- endoplasmic reticulum stress
- papillary thyroid
- cell death
- cancer therapy
- induced apoptosis
- squamous cell
- drug delivery
- water soluble
- toll like receptor
- anti inflammatory
- squamous cell carcinoma
- lymph node metastasis
- computed tomography
- oxidative stress
- childhood cancer
- cell cycle arrest
- low cost