Effect of curcumin on the expression of NOD2 receptor and pro-inflammatory cytokines in fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis (RA) patients.
Fereshteh Akbari-PapkiadehiAli Akbar Saboor-YaraghiElham FarhadiMohammad Naghi TahmasebiArash Sharafat VaziriLeila AghaghazviniMarzieh AsgariShiva PoursaniFatemeh MansouriAhmadreza JamshidiMahdi MahmoudiPublished in: Advances in rheumatology (London, England) (2023)
This study provides preliminary in vitro evidence of the potential benefits of curcumin as a nutritional supplement for RA patients. Despite the limitations of the study being an investigation of the FLSs of RA patients, the results demonstrate that curcumin has an anti-inflammatory effect on NOD2 and NF-κB genes. These findings suggest that curcumin could be a promising approach to relieve symptoms of RA.
Keyphrases
- rheumatoid arthritis
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- anti inflammatory
- prognostic factors
- disease activity
- oxidative stress
- patient reported outcomes
- interstitial lung disease
- depressive symptoms
- systemic lupus erythematosus
- physical activity
- risk assessment
- cell proliferation
- long non coding rna
- patient reported
- human health
- innate immune