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Effect of curcumin on the expression of NOD2 receptor and pro-inflammatory cytokines in fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis (RA) patients.

Fereshteh Akbari-PapkiadehiAli Akbar Saboor-YaraghiElham FarhadiMohammad Naghi TahmasebiArash Sharafat VaziriLeila AghaghazviniMarzieh AsgariShiva PoursaniFatemeh MansouriAhmadreza JamshidiMahdi Mahmoudi
Published in: Advances in rheumatology (London, England) (2023)
This study provides preliminary in vitro evidence of the potential benefits of curcumin as a nutritional supplement for RA patients. Despite the limitations of the study being an investigation of the FLSs of RA patients, the results demonstrate that curcumin has an anti-inflammatory effect on NOD2 and NF-κB genes. These findings suggest that curcumin could be a promising approach to relieve symptoms of RA.
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