Effect of High-Fat Food on the Pharmacokinetic Profile and Safety of SAF-189s, an ALK/ROS1 Inhibitor, in Healthy Chinese Adults.

Huiling QinYan TanLei DiaoAi-Min HuiZhuli WuYongchun ZhouJuan SunXiao XiangJingjun QiuWei Hu

Published in: Drugs in R&D (2023)

A high-fat meal had minimal effect on the pharmacokinetic profile of SAF-189s compared with a fasted state following a single dose of 160 mg. Administration with a high-fat meal led to a lower incidence of TEAEs.

Keyphrases

risk factors
cell death
dna damage
oxidative stress
climate change
tyrosine kinase