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Discovery of a new candidate drug to overcome cabazitaxel-resistant gene signature in castration-resistant prostate cancer by in silico screening.

Hiroshi HongoTakeo KosakaYoko SuzukiMototsugu Oya
Published in: Prostate cancer and prostatic diseases (2021)
Pimozide appears to be a promising drug to overcome CBZ resistance in CRPC by targeting AURKB and KIF20A.
Keyphrases
  • small molecule
  • genome wide
  • adverse drug
  • copy number
  • high throughput
  • drug induced
  • gene expression
  • dna methylation
  • genome wide identification
  • transcription factor
  • single cell