Vascular changes precede tomographic changes in diabetic eyes without retinopathy and improve artificial intelligence diagnostics.
Nivedhitha GovindaswamyDhanashree RatraDaleena DalanSubashchandra DoralliAnirudha A TirumalaiRajesh NagarajanThirumalesh MochiNaren ShettyAbhijit Sinha RoyPublished in: Journal of biophotonics (2020)
The purpose of this study was to evaluate early vascular and tomographic changes in the retina of diabetic patients using artificial intelligence (AI). The study included 74 age-matched normal eyes, 171 diabetic eyes without retinopathy (DWR) eyes and 69 mild non-proliferative diabetic retinopathy (NPDR) eyes. All patients underwent optical coherence tomography angiography (OCTA) imaging. Tomographic features (thickness and volume) were derived from the OCTA B-scans. These features were used in AI models. Both OCT and OCTA features showed significant differences between the groups (P < .05). However, the OCTA features indicated early retinal changes in DWR eyes better than OCT (P < .05). In the AI model using both OCT and OCTA features simultaneously, the best area under the curve of 0.91 ± 0.02 was obtained (P < .05). Thus, the combined use of AI, OCT and OCTA significantly improved the early diagnosis of diabetic changes in the retina.
Keyphrases
- optical coherence tomography
- artificial intelligence
- diabetic retinopathy
- machine learning
- big data
- optic nerve
- deep learning
- type diabetes
- end stage renal disease
- chronic kidney disease
- wound healing
- newly diagnosed
- mass spectrometry
- computed tomography
- high resolution
- contrast enhanced
- magnetic resonance imaging
- patient reported