Total synthesis and stereochemical assignment of rakicidin F.

Fangzhi HanGuangju LiuXiuhe ZhaoShunshun DuYahui DingQuan ZhangHuiting DengLiang Wang Yue Chen

Published in: Organic & biomolecular chemistry (2022)

Total synthesis of rakicidin F was accomplished in 20 linear steps (0.68% overall yield), which enabled the configural determination of its six stereogenic centers as 2 R , 15 R , 16 R , 17 S , 19 S , and 21 S . The macrolactonization of the rakicidin linear precursor was investigated and the unsuccessful results might be attributed to the steric hindrance near C16-OH.

Keyphrases

solid phase extraction
atomic force microscopy
neural network
high resolution
mass spectrometry