Clonal tracing reveals diverse patterns of response to immune checkpoint blockade.

Shengqing Stan GuXiaoqing WangXihao HuPeng JiangZiyi LiNicole TraughXia BuQin TangChenfei WangZexian ZengJingxin FuCliff MeyerYi ZhangPaloma CejasKlothilda LimJin WangWubing ZhangCollin TokheimAvinash Das SahuXiaofang XingBenjamin KrogerZhangyi OuyangHenry LongGordon J FreemanMyles BrownX Shirley Liu

Published in: Genome biology (2020)

Our study demonstrates diverse response patterns from the same ancestor cancer cells in response to ICB. This suggests the value of monitoring clonal constitution and tumor microenvironment over time to optimize ICB response and to design new combination therapies. Furthermore, as ICB response may enrich for cancer cell-intrinsic resistance signatures, this can affect interpretations of tumor RNA-seq data for response-signature association studies.

Keyphrases

rna seq
single cell
gene expression
dna methylation
electronic health record
deep learning