Effects of acute hCG stimulation on serum INSL3 and 25-OH vitamin D in Klinefelter syndrome.

Daniele SantiRichard IvellRavinder Anand-IvellLuca De ToniFlaminia FanelliMarco MezzulloCarla PelusiUberto PagottoSerena BelliAntonio R M GranataLaura RoliVincenzo RochiraTommaso TrentiAlberto Ferlin Manuela Simoni

Published in: Andrology (2020)

INSL3 secretion is independent from steroidogenesis, and its production is mostly not influenced by acute hCG stimulation both in KS men and in controls. INSL3 serum levels should be considered as a marker of Leydig cell differentiation and numbers rather than steroidogenesis. 25-VD serum levels are also not increased by a single acute hCG administration, which was not able to restore the normal concentrations of 25-VD.

Keyphrases

liver failure
respiratory failure
aortic dissection
drug induced
hepatitis b virus
intensive care unit
mechanical ventilation