Different development patterns of reward behaviors induced by ketamine and JWH-018 in striatal GAD67 knockdown mice.

Sun Mi Gu Eunchong Hong Sowoon Seo Sanghyeon Kim Seong Shoon Yoon Hye Jin Cha Jaesuk Yun

Published in: Journal of veterinary science (2024)

These results suggest that striatal GAD67 reduces GABAergic neuronal activity and may cause ketamine-induced NMDA receptor inhibition. Consequently, GAD67 downregulation induces vulnerability to the drug reward behavior of ketamine.

Keyphrases

pain management
parkinson disease
functional connectivity
climate change
high glucose
cell proliferation
drug induced
diabetic rats
high fat diet induced
prefrontal cortex
metabolic syndrome
adipose tissue
endothelial cells
adverse drug