Ultrasound-assisted catheter-directed thrombolysis versus surgical pulmonary embolectomy for intermediate-high or high-risk pulmonary embolism: a randomized phase II non-inferiority trial.

Stefan Stortecky Alexandru Grigorean Stephan WindeckerDik HegAlexander KadnerLars EnglbergerNils Kucher

Published in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2024)

In patients with intermediate-high and high-risk acute PE, USAT was not non-inferior when compared with SPE in reducing RV/LV ratio within the first 72 h. In a post hoc superiority analysis, SPE resulted in greater improvement of RV overload and reduction of thrombus burden.

Keyphrases

pulmonary embolism
phase ii
clinical trial
mycobacterium tuberculosis
open label
inferior vena cava
ms ms
phase iii
pulmonary hypertension
liver failure
placebo controlled
double blind
risk factors
drug induced
ultrasound guided
aortic dissection
mass spectrometry