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Single Injection AAV2-FGF18 Gene Therapy Reduces Cartilage Loss and Subchondral Bone Damage in a Mechanically Induced Model of Osteoarthritis.

Judith M HollanderAlexey SereginJingshu LiuEllyn XuFrancesco LuppinoTimothy E McAlindonLi ZengAlexey Seregin
Published in: Current gene therapy (2024)
FGF18 gene therapy treatment of OA joints can provide benefits to both cartilage and subchondral bone, with a high degree of localization and durability.
Keyphrases
  • gene therapy
  • bone mineral density
  • knee osteoarthritis
  • soft tissue
  • extracellular matrix
  • bone loss
  • high glucose
  • rheumatoid arthritis
  • bone regeneration
  • drug induced
  • stress induced