Identification of universal and cell-type specific p53 DNA binding.
Antonina HafnerLyubov KubloMichael TsabarGalit LahavJacob Stewart-OrnsteinPublished in: BMC molecular and cell biology (2020)
Our study reconciles previous conflicting views in the p53 field, by demonstrating that although the majority of p53 DNA binding is conserved across cell types, there is a small set of cell line specific binding sites that depend on cell state.