X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia.

Hassan AbolhassaniAhmad VosughimotlaghTakaki AsanoNils LandegrenBertrand BoissonSamaneh DelavariPaul BastardMaribel Aranda-GuillénYating WangFanglei ZuoFabian SardhHarold MarcotteLikun DuShen-Ying ZhangQian ZhangNima RezaeiOlle KämpeJean-Laurent CasanovaLennart HammarströmQiang Pan-Hammarström

Published in: Journal of clinical immunology (2021)

We report a unique IEI patient with combined ATM and TLR7 deficiencies. The two genetic defects underlie A-T and critical COVID-19 in this patient, respectively.

Keyphrases

coronavirus disease
case report
sars cov
toll like receptor
inflammatory response
immune response
dna damage
intensive care unit
early onset
dna methylation
nuclear factor
dna repair
copy number