Anti-Pneumococcal Vaccine-Induced Cellular Immune Responses in Post-Traumatic Splenectomized Individuals.
Djursun KarasartovaUmut GaziOzgur TosunAyse S GureserIbrahim T SahinerMete DolapciAysegul T OzkanPublished in: Journal of clinical immunology (2017)
According to our data, splenectomy negatively influences the levels of PCV-induced lymphoproliferation, TH1 differentiation, and cytokine release. Besides, PCV failed to induce TH17-dominant immune response which is crucial for protection against extracellular pathogens.