Macrophage M1 polarization mediated via the IL-6/STAT3 pathway contributes to apical periodontitis induced by Porphyromonas gingivalis.

Xuan ChenJinge DouZhuohui FuYang QiuLing ZouDing-Ming Huang Xuelian Tan

Published in: Journal of applied oral science : revista FOB (2022)

The activation of IL-6/STAT3 signaling pathway is involved in mediating macrophages M1 polarization in the P. gingivalis induced apical inflammatory context and may also be intimately involved in the bone loss caused by P. gingivalis infection, directing the M1 macrophage infiltration during the progression of AP.

Keyphrases

bone loss
signaling pathway
adipose tissue
cell proliferation
diabetic rats
high glucose
oxidative stress
transcription factor
epithelial mesenchymal transition
drug induced
induced apoptosis