The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women.

Vladimira MondockovaMaria AdamkovicovaMartina LukacovaBirgit GrosskopfRamona BabosovaDrahomir GalbavyMonika MartiniakovaRadoslav Omelka

Published in: BMC medical genetics (2018)

The rs9340799 polymorphism may contribute to decreased BMD in postmenopausal women from southern Slovakia; however, this is not related to higher fracture prevalence. Concurrently, both polymorphisms affected a response to analysed anti-osteoporotic therapies.

Keyphrases

postmenopausal women
bone mineral density
estrogen receptor
copy number
body composition
gene expression
dna methylation
transcription factor
replacement therapy
smoking cessation