Reproductive characteristics are associated with gene-specific promoter methylation status in breast cancer.
Lauren E McCulloughLindsay J CollinKathleen ConwayAlexandra J WhiteYoon Hee ChoSumitra ShantakumarMary Beth TerrySusan L TeitelbaumAlfred I NeugutRegina M SantellaJia ChenMarilie D GammonPublished in: BMC cancer (2019)
Our findings indicate that age at first birth, lactation and, perhaps age at menarche, are associated with gene promoter methylation in breast cancer, and should be confirmed in larger studies with robust gene coverage.