GRP78 Activity Moderation as a Therapeutic Treatment against Obesity.
Dongjin PanYunzhu YangAihua NongZhenzhou TangQingxiao LiPublished in: International journal of environmental research and public health (2022)
Glucose-regulated protein 78 (GRP78), a molecular chaperone, is overexpressed in patients suffering from obesity, fatty liver, hyperlipidemia and diabetes. GRP78, therefore, can be not only a biomarker to predict the progression and prognosis of obesity and metabolic diseases but also a potential therapeutic target for anti-obesity treatment. In this paper, GRP78 inhibitors targeting its ATPase domain have been reviewed. Small molecules and proteins that directly bind GRP78 have been described. Putative mechanisms of GRP78 in regulating lipid metabolism were also summarized so as to investigate the role of GRP78 in obesity and other related diseases and provide a theoretical basis for the development and design of anti-obesity drugs targeting GRP78.
Keyphrases
- insulin resistance
- endoplasmic reticulum stress
- metabolic syndrome
- weight loss
- type diabetes
- high fat diet induced
- weight gain
- cell surface
- high fat diet
- adipose tissue
- skeletal muscle
- cardiovascular disease
- newly diagnosed
- transcription factor
- body mass index
- prognostic factors
- single molecule
- blood glucose
- heat stress
- heat shock
- binding protein
- peritoneal dialysis