Allostatic load in early adolescence: gene / environment contributions and relevance for mental health.
Kevin W HoffmanKate T TranTyler Maxwell MooreMārtiņš M GataviņšElina VisokiGrace E DiDomenicoLaura M SchultzLaura AlmasyMatthew R HayesNikolaos P DaskalakisRan BarzilayPublished in: medRxiv : the preprint server for health sciences (2023)
AL can be quantified in youth using anthropometric and biological measures and is mapped to exposomic and polygenic risk. Main and interactive environmental and genetic effects support a diathesis-stress model. Findings suggest that both environmental and genetic risk be considered when modeling stress-related health conditions.