Cerebral Microbleeds, Cerebral Amyloid Angiopathy, and Their Relationships to Quantitative Markers of Neurodegeneration.
Charles B BeamanKrystyna KoziiSaima HilalMinghua LiuAntonio J Spagnolo-AllendeGuillermo Polanco-SerraChristopher ChenChing-Yu ChengDaniela ZambranoBurak ArikanVictor J Del BruttoClinton B WrightXena E FlowersSandra P LeskinenTatjana RundekAmanda MitchellJean Paul VonsattelEtty CortesAndrew F TeichRalph L SaccoMitchell S V ElkindDavid RohJosé Gutierreznull nullPublished in: Neurology (2022)
Superficial CMBs are associated with larger morphometric brain measures, specifically white matter volume. This association is strongest in brains with fewer CMBs, suggesting that the CMB/CAA contribution to neurodegeneration may not relate to tissue loss, at least in early stages of disease.