Genomic Tumor Correlates of Clinical Outcomes Following Organ-Sparing Chemoradiation Therapy for Bladder Cancer.

Sophia C Kamran Yuzhen Zhou Keisuke Otani Michael R Drumm Yukako Otani Shu-Lin Wu Chin-Lee Wu Adam S Feldman Matthew Wszolek Richard J Lee Philip J Saylor Jochen K Lennerz Eliezer Van Allen Henning Willers Theodore S Hong Yang Liu Elai Davicioni Ewan A Gibb William U Shipley Kent W Mouw Jason Alexander Efstathiou David T Miyamoto

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Our data identify ERCC2 mutation as a candidate biomarker associated with sensitivity and long-term response to chemoradiation in MIBC. These findings warrant validation in independent cohorts.

Keyphrases

rectal cancer
locally advanced
electronic health record
dna repair
robot assisted
big data
copy number
squamous cell carcinoma
radiation therapy
gene expression
dna damage
oxidative stress
deep learning