Minimal contribution of the hepatic uptake transporter OATP1B1 to the inter-individual variability in SN-38 pharmacokinetics in cancer patients without severe renal failure.

Ayako TsuboyaYutaro KubotaHiroo IshidaRyotaro OhkumaTomoyuki IshiguroYuya HirasawaHirotsugu AriizumiTakuya TsunodaYasutsuna SasakiNatsumi MatsumotoYusuke KondoYukana TomodaHiroyuki KusuharaKen-Ichi Fujita

Published in: Cancer chemotherapy and pharmacology (2021)

The contribution of OATP1B1 activity to inter-patient variability in the systemic exposure to SN-38 is likely minimal in patients without severe renal failure.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
prognostic factors
peritoneal dialysis