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Ciliary Neurotrophic Factor Modulates Multiple Downstream Signaling Pathways in Prostate Cancer Inhibiting Cell Invasiveness.

Giovanni TossettaSonia FantoneRosaria GesuitaGaia GoteriMartina SenzacquaFabio MarcheggianiLuca TianoDaniela MarzioniRoberta Mazzucchelli
Published in: Cancers (2022)
Our results showed that CNTF and CNTFRa were expressed in PCa and CRPC tissues and that CNTF has a pivotal role in prostate cancer environment remodeling and as a negative modulator of invasion processes of CRPC cell models.
Keyphrases
  • prostate cancer
  • signaling pathway
  • radical prostatectomy
  • single cell
  • cell therapy
  • gene expression
  • stem cells
  • oxidative stress
  • cell migration
  • endoplasmic reticulum stress
  • induced apoptosis