Impact of bariatric surgery on cerebral vascular reactivity and cognitive function: a non-randomized pilot study.
Wesley J TuckerBinu P ThomasNancy PuzziferriT Jake SamuelVlad G ZahaIldiko LingvayJaime AlmandozJing WangEdward A GonzalesR Matthew BrothersMichael D NelsonPublished in: Pilot and feasibility studies (2020)
Assessing CVR responses to a hypercapnic challenge with MRI was feasible in severely obese bariatric patients. However, no changes in whole-brain BOLD CVR were observed following bariatric surgery despite improvements in cognitive function. We recommend that future large trials assess CVR responses to cognitive tasks (rather than hypercapnia) to better define the mechanisms responsible for cognitive function improvements following bariatric surgery.
Keyphrases
- bariatric surgery
- weight loss
- obese patients
- roux en y gastric bypass
- gastric bypass
- end stage renal disease
- newly diagnosed
- resting state
- ejection fraction
- magnetic resonance imaging
- type diabetes
- double blind
- chronic kidney disease
- open label
- prognostic factors
- white matter
- clinical trial
- subarachnoid hemorrhage
- functional connectivity
- placebo controlled
- contrast enhanced
- blood brain barrier
- diffusion weighted imaging