MiR-125b Loss Activated HIF1α/pAKT Loop, Leading to Transarterial Chemoembolization Resistance in Hepatocellular Carcinoma.

Xiyang WeiLei ZhaoRuizhe RenFubo JiShuting XueJianjuan ZhangZhaogang LiuZhao MaXin Wei WangLinda WongNiya LiuJiong ShiXing GuoStephanie RoesslerXin ZhengJunfang Ji

Published in: Hepatology (Baltimore, Md.) (2020)

MiR-125b loss activated the HIF1α/pAKT loop, contributing to HCC resistance to TACE and the key nodes in this axis hold the potential in assisting patients with HCC to choose TACE therapy.

Keyphrases

radiofrequency ablation
endothelial cells
transcription factor
stem cells
squamous cell carcinoma
radiation therapy
human health
early stage
liver metastases
bone marrow
replacement therapy