Characterization of kaposiform lymphangiomatosis tissue-derived cells.

Akifumi Nozawa Michio OzekiShiho YasueSaori EndoKei NoguchiTomohiro KanayamaHiroyuki TomitaYoko AokiHidenori Ohnishi

Published in: Pediatric blood & cancer (2021)

Inhibition of the RAS/MAPK and PI3K/AKT/mTOR pathways may represent potential therapeutic targets in KLA. These patient-derived KLA cell lines will be useful research tools to elucidate KLA etiology, and could pave the way for basic, translational, and preclinical studies of this disease.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
oxidative stress
pi k akt
cell therapy
endoplasmic reticulum stress
human health
stem cells
cell proliferation