Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes.
David Z PanZong MiaoCaroline ComenhoSandhya RajkumarAmogha KokaSeung Hyuk T LeeMarcus AlvarezDorota KaminskaArthur KoJanet S SinsheimerKaren L MohlkeNicholas MancusoLinda Liliana Muñoz-HernandezMiguel Herrera-HernandezMaria Teresa Tusié-LunaCarlos Aguilar-SalinasKirsi H PietiläinenJussi PihlajamäkiMarkku LaaksoKristina M GarskePäivi PajukantaPublished in: Genome medicine (2021)
Our study discovers a novel key function for the TBX15 TF in trans regulating an adipose co-expression network of 347 adipose, mitochondrial, and metabolically important genes, including PPARG, KLF15, PPARA, ADIPOQ, and 35 obesity GWAS genes. Thus, based on our converging genomic, transcriptional, and functional evidence, we interpret the role of TBX15 to be a main transcriptional regulator in the adipose tissue and discover its importance in human abdominal obesity.
Keyphrases
- insulin resistance
- adipose tissue
- transcription factor
- metabolic syndrome
- bioinformatics analysis
- high fat diet induced
- high fat diet
- genome wide
- weight loss
- genome wide identification
- type diabetes
- skeletal muscle
- weight gain
- gene expression
- endothelial cells
- oxidative stress
- copy number
- heat shock
- induced pluripotent stem cells
- binding protein
- long non coding rna