Von Economo neurons are part of a larger neuronal population that are selectively vulnerable in C9orf72 frontotemporal dementia.
Priya Gami-PatelI van DijkenJ C van SwietenY A L Pijnenburgnull nullA J M RozemullerJ J M HoozemansA A DijkstraPublished in: Neuropathology and applied neurobiology (2019)
We show that VENs, together with GABRQ-expressing neurons, are selectively vulnerable in C9-bvFTD but are both spared in AD. This suggests they are related and that this GABRQ-expressing population of VENs and pyramidal neurons, is a key modulator of social-emotional functioning.