Association of proangiogenic and profibrotic serum markers with lung function and quality of life in sarcoidosis.
Leonie BienerJ KruseI TuletaC PizarroM KreuterS S BirringG NickenigD SkowaschPublished in: PloS one (2021)
Among patients with pulmonary sarcoidosis, baseline serum levels of VEGF and PDGF-AB were associated with pulmonary function impairment. Furthermore, PDGF-AB was associated with worsening K-BILD scores. No such association was observed for FGF-2 and TGF-ß1. VEGF and PDGF-AB may be possible prognostic and therapeutic targets in sarcoidosis as a fibrosing ILD beyond IPF.
Keyphrases
- lung function
- smooth muscle
- vascular smooth muscle cells
- interstitial lung disease
- vascular endothelial growth factor
- cystic fibrosis
- chronic obstructive pulmonary disease
- endothelial cells
- air pollution
- idiopathic pulmonary fibrosis
- pulmonary hypertension
- systemic sclerosis
- rheumatoid arthritis
- angiotensin ii
- epithelial mesenchymal transition