Plasmon-Enhanced Oxidase-Like Activity and Cellular Effect of Pd-Coated Gold Nanorods.

Local surface plasmon resonance (LSPR)-enhanced catalysis has attracted much attention recently. Palladium nanoparticles have been reported to have various nanozyme activities and exhibit promising potentials for biomedical applications. However, as Pd is a poor plasmonic metal, little attention has been paid to its LSPR-regulated nanozyme activity. Herein, by using Au nanorods (AuNRs) as a strong plasmonic core, we coated a thin layer Pd to form a rod-shaped core-shell structure. The obtained Au@PdNRs showed tunable LSPR bands in the near-infrared (NIR) spectral range inheriting from the Au core and yet an exposed Pd surface for catalysis. The oxidase-like activity was investigated in the dark and upon SPR excitation. The plasmon-enhanced activity was observed and was mainly ascribed to the local photothermal effect. Finally, to enhance biocompatibility, mesoporous silica-coated nanorods were used to detect the oxidase-like activity in cells. After being endocytosed by cells, upon plasmon excitation, the oxidase activity of Au@PdNRs could be manifested and lead to higher cytotoxicity and depolarization of mitochondrial membrane potential. Our studies highlight the feasibility of regulating the nanozyme activity of plasmonic nanostructures using their unique NIR plasmonic features with spatiotemporal control.