Interferon-γ signaling in eosinophilic esophagitis has implications for epithelial barrier function and programmed cell death.

These findings offer insight into the interplay between immune and epithelial cells in EoE. Our data illustrate the relevance of several IFN-γ-mediated mechanisms on epithelial function in the esophagus, which have the potential to impact epithelial function during inflammatory conditions.