Ex Vivo Chromosomal Radiosensitivity Testing in Patients with Pathological Germline Variants in Breast Cancer High-Susceptibility Genes BReast CAncer 1 and BReast CAncer 2 .

Tara Zuhair KassemMarius WunderleLukas KuhlmannMatthias RuebnerHanna Huebner Juliane Hoyer André Reis Peter Andreas FaschingMatthias W BeckmannCarolin C HackRainer FietkauLuitpold Valentin Distel

Published in: Current issues in molecular biology (2023)

mutations result in slightly increased chromosomal sensitivity to radiation. A few individual patients have a marked increase in radiation sensitivity. Therefore, these patients are at a higher risk for adverse therapeutic consequences.

Keyphrases

ejection fraction
newly diagnosed
copy number
prognostic factors
gene expression
dna methylation
breast cancer risk