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DNA-RNA hybrids: the risks of DNA breakage during transcription.

Andrés AguileraBelén Gómez-González
Published in: Nature structural & molecular biology (2017)
Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain unclear. Emerging evidence indicates that DNA breaks stimulate DNA-RNA hybrid formation. Here, we discuss the possibility that formation of hybrids may be an inevitable risk of DNA breaks that occur within actively transcribed regions. While such hybrids must be removed to permit repair, their potential role as repair intermediates remains to be established.
Keyphrases
  • circulating tumor
  • cell free
  • single molecule
  • nucleic acid
  • circulating tumor cells
  • risk assessment
  • dna methylation
  • copy number