Short- and long-interval intracortical inhibition in EPM1 is related to genotype.
Katri SilvennoinenLaura SäisänenJelena HyppönenSaara M RissanenPasi A KarjalainenSasha D'AmbrosioDiego Jimenez-JimenezSara ZagagliaJohn C RothwellSimona BalestriniSanjay M SisodiyaPetro JulkunenEsa MervaalaReetta KälviäinenPublished in: Epilepsia (2022)
Our results strengthen the finding of deranged γ-aminobutyric acid (GABA)ergic inhibition in EPM1. LICI and SICI may have use as markers of GABAergic impairment in future trials of disease-modifying treatment in this condition. Whether a higher number of expansion repeats leads to greater GABAergic impairment warrants further study.
Keyphrases