Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.
Christoph H MayrArunima SenguptaSara AsgharpourMeshal AnsariJeanine C PestoniPaulina OgarIlias AngelidisAndreas LiontosJosé Alberto Rodriguez-CastilloNiklas J LangMaximilian StrunzDiana Porras-GonzalezMichael GerckensDe Sadeleer LaurensBettina OehrleValeria Viteri-AlvarezIsis E FernandezMichelle TallquistMartin IrmlerJohannes BeckersOliver EickelbergGabriel Mircea StoleriuJürgen BehrNikolaus KneidingerWim A WuytsRoxana Maria WasnickAli Oender YildirimKatrin AhlbrechtRory Edward MortyChristos SamakovlisFabian J TheisGerald BurgstallerHerbert B SchillerPublished in: The European respiratory journal (2024)
Our study reveals the convergence of spatially and transcriptionally distinct fibroblast lineages into transcriptionally uniform myofibroblasts and identifies SFRP1 as a modulator of TGFβ1 driven fibroblast phenotypes in fibrogenesis. These findings are relevant in the context of therapeutic interventions that aim at limiting or reversing fibroblast foci formation.