Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore.

Pei Sze NgRick Acm BoonenEldarina WijayaChan Eng ChongMilan SharmaSabine KnaupShivaani MariapunWeang Kee HoJoanna LimSook-Yee YoonNur Aishah Mohd TaibMee Hoong SeeJingmei LiSwee Ho LimErn Yu TanBenita Kiat-Tee TanSu-Ming TanVeronique Kiat-Mien TanRob Martinus van DamKartini RahmatCheng Har YipSara CarvalhoCraig LuccariniCaroline BaynesAlison M DunningAntonis AntoniouHaico van AttikumDouglas F EastonMikael HartmanSoo-Hwang Teo

Published in: Journal of medical genetics (2021)

Despite genetic and lifestyle differences between Asian and other populations, the population prevalence of PALB2 PTVs and associated relative risk of breast cancer, are similar to those reported in European populations.

Keyphrases

copy number
polycystic ovary syndrome
risk factors
genetic diversity
metabolic syndrome
physical activity
intellectual disability
genome wide
weight loss
protein protein
pregnancy outcomes
amino acid
binding protein
type diabetes
pregnant women
gene expression
small molecule
skeletal muscle