CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer.

Haiyang ZhangTing DengRui LiuTao NingHaiou YangDongying LiuQiumo ZhangDan LinShaohua GeMing BaiXinyi WangLe ZhangHongli LiYuchong YangZhi JiHailong WangGuoguang YingYi Ba

Published in: Molecular cancer (2020)

The present study demonstrates that CAFs secrete exosomal miR-522 to inhibit ferroptosis in cancer cells by targeting ALOX15 and blocking lipid-ROS accumulation. The intercellular pathway, comprising USP7, hnRNPA1, exo-miR-522 and ALOX15, reveals new mechanism of acquired chemo-resistance in GC.

Keyphrases

cell proliferation
long non coding rna
cell death
long noncoding rna
photodynamic therapy
cancer therapy
papillary thyroid
signaling pathway
dna damage
squamous cell carcinoma
childhood cancer
simultaneous determination