Restoration of Nusinersen Levels Following Treatment Interruption in People With Spinal Muscular Atrophy: Simulations Based on a Population Pharmacokinetic Model.
Drew MacCannellZdenek BergerJanbernd KirschnerEugenio MercuriMichelle Anne FarrarSusan T IannacconeNancy L KuntzRichard S FinkelMarta ValenteFrancesco MuntoniPublished in: CNS drugs (2022)
Prolonged treatment interruptions lead to suboptimal CSF levels of nusinersen. The optimal regimen to restore nusinersen CSF levels depends on the interval since the last maintenance dose was administered.
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