Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury.

Jiangnan HuLefu ChenXujun HuangKe WuSaidan DingWeikan WangBrian WangCharity SmithChanghong RenHaoqi NiQichuan ZhuGeJianjing Yang

Published in: Stem cell research & therapy (2019)

Taken together, our data suggest that MDL28170 improves BMSC transplantation microenvironment and enhances the neurological function restoration after TBI via increased survival rate of BMSCs. We suggest that the calpain inhibitor, MDL28170, could be pursued as a new combination therapeutic strategy to advance the effects of transplanted BMSCs in cell-based regenerative medicine.

Keyphrases

traumatic brain injury
bone marrow
cell therapy
mesenchymal stem cells
stem cells
single cell
severe traumatic brain injury
electronic health record
big data
free survival