A statistical approach to optimizing paper spray mass spectrometry parameters.
Christine SkaggsLindsey KirkpatrickWilliam R A WichertNicole SkaggsNicholas E ManickePublished in: Rapid communications in mass spectrometry : RCM (2020)
The statistical optimization procedure undertaken here increased the mass spectral signal intensity by more than a factor of 40. This statistical method of screening followed by optimization experiments proved faster and more efficient, and produced more drastic improvements than typical one-factor-at-a-time experiments.