Screening for subclinical rheumatic heart disease: addressing borderline disease in a real-world setting.
Luke David HunterAlfonso J K PecoraroAnton F DoubellMark J MonaghanGuy W LloydCarl J LombardPhilip G HerbstPublished in: European heart journal open (2021)
In a real-world, large-scale screening project, the adoption of a mechanistic evaluation based on the systematic identification of ISS-related MR markedly reduced the number of WHF 'screen-positive' cases misclassified as WHF 'borderline RHD'. Implementing strategies that reduce this misclassification could reduce the cost- and labour burden on large-scale RHD screening programmes.