Iridium-Catalyzed Branch-Selective and Enantioselective Hydroalkenylation of α-Olefins through C-H Cleavage of Enamides.

Xin SunEn-Ze LinBi-Jie Li

Published in: Journal of the American Chemical Society (2022)

Catalytic branch-selective hydrofunctionalization of feedstock α-olefins to form enantioenriched chiral compounds is a particularly attractive yet challenging transformation in asymmetric catalysis. Herein we report an iridium-catalyzed asymmetric hydroalkenylation of α-olefins through directed C-H cleavage of enamides. This atom-economical addition process is highly branch-selective and enantioselective, delivering trisubstituted alkenes with an allylic stereocenter. DFT calculations reveal the origin of regio- and enantioselectivity.

Keyphrases

density functional theory
molecular dynamics
dna binding
molecular dynamics simulations
gene expression
single cell
solid state
mass spectrometry
crystal structure
capillary electrophoresis