Blood-Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease.

Zixuan LinSandeepa SurPeiying LiuYang LiDengrong JiangXirui HouJacqueline DarrowJay J PillaiSevil YasarPaul RosenbergMarilyn AlbertAbhay MoghekarHanzhang Lu

Published in: Annals of neurology (2021)

These findings provide early evidence that BBB breakdown is related to both AD and vascular risks, but their effects can be differentiated by spatial scales. BBB permeability to small molecules has a greater impact on cognitive performance. ANN NEUROL 2021;90:227-238.

Keyphrases

blood brain barrier
cerebral ischemia
cognitive decline
endothelial cells
neural network
climate change
mild cognitive impairment