Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer.
Sophie J CowmanDaniel G FujaXian-De LiuRebecca S Slack TidwellNeelima KandulaDeepika SirohiArchana M AgarwalLyska L EmersonSheryl R TrippJeffrey S MohlmanMiekan StonhillGuillermina GarciaChristopher J ConleyAdam A OlaldeTimothy SargisAdela Ramirez-TorresJose A KaramChristopher G WoodKanishka SircarPheroze TamboliKenneth M BoucherBenjamin MaughanBenjamin T SpikeThai H HoEric JonaschMei Yee KohPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
These findings highlight a potential role of TAM HIF-1α in ccRCC progression and support the reevaluation of HIF-1α as a therapeutic target and marker of disease progression.