Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice.

Kåre Kryger VølsMads Kjelgaard-HansenCarsten Dan LeyAxel Kornerup HansenMaj Petersen

Published in: Animal models and experimental medicine (2020)

When applying a delayed on-demand treatment regimen to hemophilic mice subjected to an induced knee hemarthrosis, the degree of histopathological changes on Day 14 reflected the bleed volume prior to initiation of treatment.

Keyphrases

total knee arthroplasty
combination therapy
adipose tissue
high fat diet induced
skeletal muscle