Tumor-associated macrophages (TAMs) modulate response to HER2-targeted agents in a humanized mouse model of breast cancer.

Mauro LoiG SalvatoreM SottiliL CalosiI DesideriC BecheriniV SalvestriniL P CicconeG StocchiI MeattiniG FrancoliniM MangoniL Livi

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2022)

Activity of TP is modulated by TAM infiltrate, that is inhibited by concurrent administration of Paclitaxel. To enhance the effect of anti-HER2-targeted therapies and minimize chemotherapy-related side effects, modulation of TAM should be considered in novel therapeutic combinations.

Keyphrases

mouse model
locally advanced
rectal cancer
chemotherapy induced
cancer therapy
squamous cell carcinoma
monoclonal antibody
radiation therapy
breast cancer risk
drug induced